我们与国内外众多合作单位联合发表的部分文章与摘要(包括 CTCCTEC,肿瘤细胞与分子生物学,脑神经学,内分泌学,免疫学,血液学,病原微生物学,C-反应蛋白 CRP,免疫脂质体溶破技术应用等



  • 文章索引

  • 中文推送(点击推送题目下载)

    • 57.P. P. Lin (2020) Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis. Cells 9:1539

      关键词:CTEC、肿瘤细胞内皮化、肿瘤微环境、肿瘤新血管生成、肿瘤转移、hypoxia、EMT、EndoMT
      合作单位:赛特生物
    • 56.  程洪艳,李一林,王书航,刘颖,王丹丹,林平,昌晓红 (2020) 应用SE-iFISH同步联合检测异倍体CTC与CTEC的重要临床意义。《临床实验室》(Clinical Laboratory) 14(5):43-48

      关键词:瘤标、异倍体、循环肿瘤血管内皮细胞CTEC、SE-iFISH
      合作单位:北京大学人民医院妇科肿瘤中心、北京大学肿瘤中心、北京肿瘤医院、中国国家癌症中心、中国医学科学院、北京协和医学院肿瘤医院 、赛特生物
    • 55. L. Zhang, X. Zhang, Y. Liu, T. Zhang, Z. Wang, M. Gu, Y. Li, D.D. Wang, W. Li, P.P. Lin (2020) PD-L1+ aneuploid circulating tumor endothelial cells (CTECs) exhibit resistance to the checkpoint blockade immunotherapy in advanced NSCLC patients. Cancer Lett 469:355-366

      关键词:非小细胞肺癌、PD-L1+ CTC及CTEC、免疫治疗耐药
      合作单位:首都医科大学附属北京胸科医院、北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 54. Y. Zhao, J. Li, D. Li, Z. Wang, J. Zhao, X. Wu, Q. Sun, P.P. Lin, P. Plum, A. Damanakis, F. Gebauer, M. Zhou, Z. Zhang, H. Schlosser, K-W Jauch, P.J. Nelson, C.J. Bruns (2020) Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers. Semin Cancer Biol 60:334-343

      关键词:肿瘤寡转移OMD、肿瘤微环境、CTC及CTEC
      合作单位:德国科隆大学、德国慕尼黑大学、上海复旦大学肿瘤中心、上海长海医院、赛特生物
    • 53. X. Liu, J. Li, B. L. Cadilha, A. Markota, C. Voigt, Z. Huang, P. P. Lin, D. D. Wang, J. Dai, G. Kranz, A. Krandick, D. Libl, H. Zitzelsberger, I. Zagorski, H. Braselmann, M. Pan, S. Zhu,Y. Huang, S. Niedermeyer, C. A. Reichel, B. Uhl, D. Briukhovetska, J. Suárez, S. Kobold, O. Gires, and H. Wang (2019) Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis (SA Highlights). Science Advances 5, eaav4275

      关键词:乳腺癌转移、肿瘤动物模型、原代肿瘤细胞培养、EpCAM+ CTCs与DTCs、单细胞测序
      合作单位:上海交大附属上海第一人民医院、德国慕尼黑大学、GSK制药、复旦大学生科院、南京医科大学、赛特生物等
    • 52. Y. Wang, Y. Liu, L. Zhang, L. Tong, Y. Gao, F. Hu, P. P. Lin, B. Li, T. Zhang (2019) Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer. J Cancer Res Clin Oncol 145:2911-2920

      关键词:SCLC及NSCLC、肺癌定向肝转移、预后、间质化CTC
      合作单位:首都医科大学附属北京胸科医院、赛特生物
    • 51. Y. Li, X. Zhang, D. Liu, J. Gong, D. Wang, S. Li, Z. Peng, Y. Li, X. Wang, P. Lin, M. Li, and L. Shen (2018) Evolutionary expression of HER2 conferred by chromosome aneuploidy on circulating gastric cancer cells contributes to developing targeted and chemotherapeutic resistance (CCR Highlights). Clin Cancer Res 24:5261-71

      关键词:胃癌、CTC HER2与组织 HER2、CTC与耐药及不良预后
      合作单位:北京大学肿瘤中心、北京肿瘤医院、美国奥克拉荷马大学医学中心、赛特生物
    • 50. P. Lin, J. Li, D. Wang, O. Gires, H. Wang (2018) EpCAM differentially expressed on circulating and disseminated tumor cells promotes tumor metastasis in breast cancer patients. Cancer Res 78:1059a

      关键词:乳腺癌转移、EpCAM+ CTCs和DTCs、疗效和预后
      合作单位:上海交大附属上海第一人民医院、德国慕尼黑大学、赛特生物等
    • 49. J. Zhang, H. Shi, T. Jiang, Z. Liu, P.P. Lin, and N. Chen (2018) Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma. BMC Cancer 18:1133

      关键词:鼻咽癌、CTC检测、肿瘤分期、化疗疗效、耐药
      合作单位:华西医院肿瘤中心、肿瘤放疗科及生物治疗国家重点实验室、赛特生物
    • 48. P. Lin (2018) Aneuploid CTC and CEC. Diagnostics 8(2):26(1-13)

      关键词:CTC与CTEC、染色体异常、SE-i•FISH、单细胞测序
      合作单位:赛特生物
    • 47. L. Wang, Y. Li, J. Xu, A. Zhang, X. Wang, R. Tang, X. Zhang, H. Yin, M. Liu, D. Wang, P. Lin, L. Shen, J. Dong (2018) Quantified postsurgical small cell size CTCs and EpCAM+ circulating tumor stem cells with cytogenetic abnormalities in hepatocellular carcinoma patients determine cancer relapse. Cancer Lett 412:99-107

      关键词:肝癌、术后复发、小细胞CTC、EpCAM+ CTC、CTM
      合作单位:清华大学北京长庚医院、北京大学肿瘤中心、北京肿瘤医院、解放军301总医院、赛特生物
    • 46. X. Li, Y. Zhang, J. Ding, M. Wang, N. Li, H. Yang, K. Wang, D. Wang, P. Lin, M. Li, Z. Zhao, and P. Liu (2017) Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis. Oncotarget 9:2705-14

      关键词:乳腺癌脑转移、原代肿瘤细胞培养、NGS、指导个体化筛药
      合作单位:大连医科大学肿瘤干细胞研究所、大连医大第二附属医院、赛特生物
    • 45. P. Lin, O. Gires, D. Wang, L. Li and H. Wang (2017) Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells. Sci Rep 7:9789

      关键词:CD31、异倍体循环血管内皮细胞CTEC、肿瘤血管生成、CTC活性
      合作单位:上海市第一人民医院肿瘤中心、德国慕尼黑大学、赛特生物
    • 44. 由磊,赵烨,阚秀,李一林,王东民,张爱群,王红霞,刘颖,王丹丹,林平,郑直 (2017) 同步原位检测 CTC 多重瘤标蛋白表达与染色体异倍体的意义及应用。《临床与实验病理学杂志》 (J Clin Exp Pathol) 33:297-302

      关键词:液体活检、CTC、临床意义
      合作单位:北京协和医院、中国医学科学院基础医学研究所、北京肿瘤医院、解放军301医院、北京大学第一医院、赛特生物
    • 43. Y. Li, X. Zhang, D. Liu, J. Gong, D.D. Wang, P.P. Lin, and L. Shen (2017) Dynamic acquisition of HER2 expression on circulating tumor cells in gastric cancer patients correlates to developing therapeutic resistance. Cancer Res 77:3795a

      关键词:胃癌、HER2+ CTC、耐药
      合作单位:北京大学肿瘤中心、北京肿瘤医院、美国奥克拉荷马大学医学中心、赛特生物
    • 42. H. Wang, N. Stoecklein, P. Lin and O. Gires (2017) Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion (Review). Oncotarget 8:1884-1912

      关键词:CTC与DTC检测、治疗靶标
      合作单位:上海交通大学附属上海市第一人民医院肿瘤中心、德国慕尼黑大学、赛特生物
    • 41. Y. Li, X. Zhang, J. Gong, Q. Zhang, J. Gao, Y. Cao, D. D. Wang, P.P. Lin, and L. Shen (2016) Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer. Chin J Cancer Res 28:579-588

      关键词:晚期胃癌、8号染色体异倍体、CTC、预后
      合作单位:北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 40. P. Lin (2016) NGS analysis of the single CTC or DTC isolated and subtyped by the integrated subtraction enrichment and immunostaining-FISH. Cancer Res 76:489a

      关键词:EMT、差相富集 、CTC亚类
      合作单位:赛特生物
    • 39. P. Lin (2015) Integrated EpCAM-independent subtraction enrichment and iFISH strategies to detect and classify disseminated and circulating tumors cells. Clin Transl Med 4(38):1-7

      关键词:CTC分类、临床意义
      合作单位:赛特生物
    • 38. F. Ge, H. Zhang, D. Wang, L. Li and P. Lin (2015) Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells. Oncotarget 6 (29): 27049-27064

      关键词:CTC 和 DTC 亚型、差相富集 (SE)、原位表型和核型分析 (iFISH)
      合作单位:北京朝阳医院、复旦大学华山医院、赛特生物
    • 37. P. Lin, L. Li, and D. Wang (2015) A novel integrated iFISH technology to detect and characterize non-hematopoietic heteroploid CTC subtypes with or without expressing vimentin or other tumor biomarkers. Cancer Res 75:557

      关键词:iFISH 技术、检测并分型 CTC
      合作单位:赛特生物
    • 36. J. Jiang, D. Wang,  M. Yang, D. Chen, L. Pang, S. Guo, J. Cai, J.P. Wery, L. Li, H. Li,and P. Lin (2015) Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model. Oncotarget 6(17):15639-15651

      关键词:CTC 亚型、转移性 PDX、耐药、表型和核型分析 (iFISH)
      合作单位:北京大学天然药物与仿生药物国家重点实验室、中美冠科生物技术有限公司、赛特生物
    • 35. Y.Li, X. Zhang, S. Ge, J. Gao, J. Gong, M. Lu, Q. Zhang, Y. Cao, D. Wang, P. Lin, L. Shen (2014) Clinical Significance of Phenotyping and Karyotyping of Circulating Tumor Cells in Patients with Advanced Gastric Cancer. Oncotarget  5(16):6594-6602

      关键词:胃癌、CTC、核型分析、耐药监测
      合作单位:北京大学肿瘤中心、北京肿瘤医院、赛特生物
    • 34. R. Ran, L. Li, M. Wang, S. Wang, Z. Zheng, and P. Lin (2013) Determination of EGFR mutation in single cells microdissected from enriched lung tumor cells in peripheral blood. Anal. Bioanal. Chem. 405(23):7377-7382

      关键词:肺癌、CTC、单细胞测序、EGFR 突变
      合作单位:北京协和医院、中国科学院基础医学研究所、赛特生物
    • 33. J. Jiang, D.D. Wang, M. Yang, D. Chen, S. Guo, J. Cai, L. Li, J-P. Wery, P. Lin, and H. Li (2013) Metastatic PDX modeling displays correlation between CTC and metastatic potential, both inhibited by chemotherapy. Mol. Cancer Ther. 12:157

      关键词:PDX 模型、CTC 、转移潜能
      合作单位:中美冠科生物技术有限公司、赛特生物
    • 32. Q. Chen, F. Ge, W. Cui, F. Wang, Z. Yang, Y. Guo, L. Li, R. Bremner, and P. Lin (2013) Lung Cancer Circulating Tumor Cells Isolated by the EpCAM-Independent Enrichment Strategy Correlate with Cytokeratin 19-Derived CYFRA21-1 and Pathological Staging. Clin. Chim. Acta 419:57-61

      关键词:肺癌、CTC、病理分期、CYFRA21-1
      合作单位:北京协和医院、世纪坛医院、圣约瑟夫医院、赛特生物
    • 31. X. Zhou, L. Li, H. Hao, S. Wang, Z. Guo, M. Wang, L. Zhang, W. Zhong, R. Ran, X. Zhang, L. Xu, and P. Lin (2010) Circulating tumor cells as a prognostic and predictive indicator in advanced lung cancer patients. Oncol. Progress 8(5):484-490

      关键词:肺癌、CTC、疗效
      合作单位:北京协和医院、首都医科大学附属北京胸科医院、赛特生物
    • 30. C. Wu, H. Hao, L. Li, X. Zhou, Z. Guo, L. Zhang, X. Zhang, W. Zhong, H. Guo, R. Bremner, and P. Lin (2009) Preliminary investigation of the clinical significance of detecting circulating tumor cells enriched from lung cancer patients. J. Thorac. Oncol. 4:30-36

      关键词:循环肿瘤细胞 (CTC) 、肺癌、CT、化疗疗效评估、复发
      合作单位:北京协和医院、北京微生物与流行病研究所、赛特生物
    • 29. P. Lin, C. Lavoie, T. Fischer, H. Huang, and M. Farquhar (2009) Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells. Mol. Neurodegeneration. 4:1-16

      关键词:G-蛋白、调节性细胞外泌
      合作单位:赛特生物
    • 28. L. Li, X. Zhou, H. Hao, M. Wang, Z. Guo, S. Wang, X. Xing, G. Harvie, E. Vuong, W. Shi, M. Tang, J. Rao, T. Reid, R. Bremner, P. Lin, J. Xu (2008) Detection of circulating tumor cells in newly diagnosed or relapsed lung cancer patients and the significance of CTC enumeration in patient staging. Cancer Res. 68:3691

      关键词:非小细胞肺癌、CTC 计数、临床分期、影像学
      合作单位:加州大学洛杉矶分校、加州大学圣地亚哥分校、圣约瑟夫医院、赛特生物
    • 27. D. Wang, Y, Liu, Y. Liu, C. Wang, H. Bao, H. Hao, S. Wang, Y. Zhang, H. Yu, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, P. Lin, J. Xu (2008) Enrichment and detection of circulating tumor cells in breast cancer patients. Cancer Res. 68:3692

      关键词:乳腺癌、分期与疗效、CTC 计数
      合作单位:北京大学医学中心、加州大学圣地亚哥分校、赛特生物
    • 26. H. Guo, H. Hao, Z. Li, Y. Zhu, J. Sun, F. Ge, S. Wang, X. Xing, G. Harvie, E. Vuong, J. Rao, R. Bremner, T. Reid, P. Lin, J. Xu (2008) Preliminary investigation of lung cancer CTC distribution in patient body circulation. Cancer Res. 68:3694

      关键词:肺静脉、桡动脉和外周血 CTC 、显著性差异
      合作单位:北京协和医院、加州大学圣地亚哥分校、赛特生物
    • 25. Y, Chen, H. Bao, C. Zhou, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, H. Qiu, Y. Xiao, H. Wu, M. Mei, C. Lu, P. Lin and J. Xu (2008) Detection of circulating tumor cell in patients with colorectal cancer and its potential implication. Cancer Res. 68:3696

      关键词:结直肠癌、CTC、肿瘤侵袭性
      合作单位:北京协和医院、加州大学圣地亚哥分校、加州大学洛杉矶分校、赛特生物
    • 24. X. Zhou, L. Li, M. Wang, L. Zhang, P. Lin and J. Xu (2008) Circulating tumor cells (CTC) as a prognostic and predictive factor in lung cancer patients. J Clin Oncol 26(15):22201

      关键词:肺癌、CTC、预后
      合作单位:北京协和医院、赛特生物
    • 23. C. Ren, P. He, J. Zhang, Z. Zheng, Y. Xu, L. Zhou, H. Qiao, C. Wang, P. Zhao, W. Shi, M. Tang, P. Lin, and J. Xu (2007) Detecting circulating tumor cells in peripheral blood of pancreatic cancer patients using a negative selection strategy. Cancer Res. 67:5445

      关键词:差相富集、CTC、胰腺癌
      合作单位:北京协和医院、赛特生物
    • 22. W. Shi, T. Reid, M. Tang, G. Harvie, H. Tao, G. Tao, P. Lin, and J. Xu (2007) Detection of circulating cancer cells from patient blood samples and correlation with anti-cancer therapy. Cancer Res. 67:5444

      关键词:肺癌、CTC、化疗
      合作单位:北京协和医院、加州大学圣地亚哥分校、赛特生物
    • 21. H. Yu, P. Lin, Y. Xu, Y. Zhou, Q. Sun, and J. Xu (2007) Breast cancer and circulating tumor cell (Review). Chn. J. Med. Lab. Tech. 8(3):215-218

      关键词:乳腺癌、循环肿瘤细胞
      合作单位:北京协和医院、赛特生物
    • 20. Y. Chen, P. Lin, S. Qiu, XX. Peng, K. Loi, MG Farquhar and JY. Zhang (2007) Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. Int. J. Oncol. 30(5):1137-44

    • 19. P. Lin, F. Li, Y. Zhang, H. Huang, G. Tong, M. Farquhar and H. Xu (2007) Calnuc binds to Alzheimer’s beta-amyloid precursor protein and affects its biogenesis. J. Neurochem. 100:1505-1514

    • 18. Y. Chen, P. Lin, K. Looi, R. Megliorino, and J. Zhang (2005) Autoantibodies to calcium binding protein Calnuc might be a potential marker in colon cancer detection. Cancer Res. 65:561

    • 17. P. Lin, C. Ren, X. Zhao, L. Li, Y. Qiao , G. Harve, H. Tao, E. Vuong, G. Tao, M, Huang, L. Wu, and J. Xu (2005) Role of detecting circulating tumor cell in clinical cancer diagnosis and therapy. Chn. J. Lab. Tech. 1 (1):1-6

      关键词:循环肿瘤细胞检测、临床肿瘤诊断和治疗
      合作单位:北京协和医院、赛特生物
    • 16. Y-W. Zhang, W-J Luo, H. Wang, P. Lin, K.S. Vetrivel, F. Liao, F. Li, P.C. Wong, M.G. Farquhar, G. Thinakaran, and H. Xu (2005) Nicastrin is critical for stability and trafficking but not association of other presenilin/g-secretases components. J. Biol. Chem. 280:17020-17026

    • 15. C. Lavoie, T. Meerloo, P. Lin , and M.G. Farquhar (2002) Calnuc, an EF-Hand Ca2+-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT-20 cells. Mol. Endocrinol. 16:2462-2474

    • 14. T.S.Weiss, C.E. Chamberlain, T. Takeda, P. Lin, K.M. Hahn, and M.G. Farquhar (2001) Galphai3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer (FRET) of green fluorescent protein fusion proteins. Proc. Natl. Acad. Sci. USA. 98:14961-14966

    • 13. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (2000) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal alpha5-helix region of Galphai3. Proc. Natl. Acad. Sci. USA. 97:674-679

    • 12. P. Lin, C. Lavoie, T. Fischer and M.G. Farquhar (2000) Calnuc regulates ACTH secretion in AtT-20 cells. Mol. Biol. Cell 11:50

    • 11. P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1999) Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. J. Cell Biol. 145:279-289

    • 10. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (1999) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal region of Galphai3. Mol. Biol. Cell 10:418

    • 9.P. Lin, H. Le-Niculescu, R. Hofmeister, J.M. McCaffery, M. Jin, H. Hennemann, T. McQuistan, L. De Vries, and M.G. Farquhar (1998) The mammalian Ca2+ binding protein, nucleobindin (CALNUC), is a Golgi resident protein. J. Cell Biol. 141:1515-1527

    • 8.P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1998) Overexpression of CALNUC increases thapsigargin relesable Ca2+ storage in the Golgi. Mol. Biol. Cell 9:99

    • 7. H. Le-Niculescu, P. Lin, M. Jin, H. Hennemann, D. Heinegard, T. McQuistan, J. M. McCaffery, N. Watson, L. De Vries, and M.G. Farquhar (1997) Characterization of a Golgi-associated EF-hand/ Ca2+ binding protein that interacts with heterotrimeric Galphai protein subunits. Mol. Biol. Cell 8:338

    • 6. Y-P. Li, G. Curley, M. Lopez, M Chavez, R. Glew, A. Aragon, H. Kumar, and O.G. Baca (1996) Protein-tyrosine phosphatase activity of Coxiella Burnetii that inhibits human neutrophils. Acta Virologica 40:263-272

    • 5. P. Lin, C. Mold, and T.W. DuClos (1995) Characterization of the C-reactive protein (CRP) receptor on the human monocytic cell line THP-1 (704). Immunol. Today 16(7):305-62

    • 4. O.G. Baca, Y-P. Li, and H. Kumar  (1994) Survival of the Q fever agent Coxiella Burnetii in the phagolysosome. Trends in Microbiol. 2(12):476-480

    • 3. Y-P. Li, C. Mold, and T.W. DuClos (1994) Sublytic Complement Attack Exposes C-Reactive Protein Biding Sites on Cell Membranes. J. Immunol. 152:2995-3005

    • 2. T. Nakagaki, P. Lin, and W. Kisiel (1992) Activation of human factor VII by the prothrombin activator from the venom of Oxyuranus Scutellatus(taipan snake). Thrombosis Res. 65:105-116

    • 1. P. Lin, Q.S. Lin, and S.Q. Nie (1992) Primary study of application of liposome immunolysis assay on drug monitoring. Prog. Clin. Biochem.p515-516. Editors: K. Miyai, T. Kanno, and E. Ishikawa. Excerpta Medica Publishing.

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